Antigen processing and presentation

Poster

Antigen processing and presentation

Pamela Wearsch and Peter Cresswell

Nature Reviews Immunology
Volume 15, No 7 July 2015

Article body

The process by which antigen-presenting cells digest proteins from inside or outside the cell and display the resulting antigenic peptide fragments on cell surface MHC molecules for recognition by T cells is central to the body's ability to detect signs of infection or abnormal cell growth. As such, understanding the processes and mechanisms of antigen processing and presentation provides us with crucial insights necessary for the design of vaccines and therapeutic strategies to bolster T-cell responses.

This poster provides an updated overview of the intracellular pathways and mechanisms by which antigens are captured, processed and loaded onto MHC class I, class II and CD1d molecules for presentation to T cells. The poster is freely available thanks to support from STEMCELL Technologies.

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The immune response to HIV

Poster

The immune response to HIV

Nina Bhardwaj, Florian Hladik and Susan Moir

Nature Reviews Immunology
Volume 15, No 7 July 2015

Article body

A global research effort over the past three decades has discovered more about HIV than perhaps any other pathogen. Immunologists continue to be intrigued by the capacity of HIV to effectively knock out an essential component of the adaptive immune system — CD4⁺ T helper cells. Based on a clearer understanding of HIV infection and the response to it, the field has now entered an era of renewed optimism for the development of a successful vaccine.

This Poster summarizes how HIV establishes infection at mucosal surfaces, the ensuing immune response to the virus involving dendritic cells, B cells and T cells, and how HIV subverts this response to establish a chronic infection.

The Poster is freely available thanks to support from STEMCELL Technologies.

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Dendritic cells: controllers of adaptive immunity

Poster

Dendritic cells: controllers of adaptive immunity

Miriam Merad

Nature Reviews Immunology

Volume 15, No 7 July 2015

Article body

Dendritic cells (DCs) are a heterogenous population of antigen-presenting cells that have crucial roles in promoting both pro- and anti-inflammatory immune responses. They monitor the body's tissues and can integrate multiple signals from the environment in order to initiate an appropriate adaptive immune response. Inflammatory signals promote DC activation and their migration to draining lymphoid tissues to prime effector T cell responses. However, in the steady state, DCs promote tissue homeostasis by supporting the induction of regulatory T cells.

This Poster provides an overview of some of the key ways in which DCs contribute to adaptive immunity.

The Poster is freely available thanks to support from BioLegend.

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